We, in addition, demonstrated the efficacy of cold atmospheric plasma (CAP), a redox regulatory tool and an emerging onco-therapeutic with selectivity against cancer cells, in synergizing with IFNγ towards the trigger of colorectal cancer cell ferroptosis via the IFNγ/IFNR2/APC/TCF4/GPX4 axis that may represent an innovative remedy for colorectal cancer treatment. Here, TCF4 is linked to colorectal cancer.