HNRNPA2B1 promotes the progression of Esophageal Cancer by up-regulating ACLY and ACC1 [31], contributes to epithelial-to-mesenchymal transition by MST1R-Akt axis in head and neck cancer [32], promotes apoptosis by regulating Lin28B in ovarian cancer [33], In breast cancer, HNRNPA2B1 is regulated by MIR-204 and affects the invasion and metastasis of breast cancer cells [34]. This evidence concerns the gene AKT1 and head and neck cancer.