CDK8 and infection: In contrast, we found that treatment of RBH-infected CDK8 KO cells with the histone deacetylase inhibitor SAHA, or the bromodomain inhibitors JQ1 and IACS-957 (18) failed to recapitulate the level of productive infections observed for wild-type cells (Fig. 10C, SAHA, JQ1, IACS-9571).