This non‐canonical signaling can occur, for example, via the interaction of FGFs with HSPG syndecans.[87] Collectively, the results are in agreement with previous reports of fibrin gels in cancer cell culture, where soft fibrin gels have been more successful in maintaining cancer stem cell ‐like features than stiffer ones.[88, 89] Notably, cells cultured in stiff fibrin were not committed to a differentiated state, as the morphological changes could be reversed by allowing softening of the gel. The gene discussed is SDC1; the disease is cancer.