In the APP/PS1 mouse model of Alzheimer’s disease, Axl and MerTK have been shown to be important for microglia migration to amyloid plaques.73 Genetic ablation of Axl and/or Mertk led to accelerated death of the animals,74 indicating a protective role for these receptors against disease progression. The gene discussed is AXL; the disease is early-onset autosomal dominant Alzheimer disease.