To examine the effect of UHRF1 expression on the function of renal cancer cells, we compared the expression of UHRF1 in normal renal cells and renal carcinoma cells and found that UHRF1 was significantly upregulated in renal carcinoma cells than normal renal cells (HK-2) and was highly expressed in A498 and 769-P cells (Figure 1(a)). This evidence concerns the gene UHRF1 and renal carcinoma.