ACHE and Alzheimer disease: Interestingly, secondary metabolites produced by marine fungi are now found to have neuroprotective properties.73 Additionally, research using animal models revealed that COX-2’s inhibitory action lowers inflammation, which is essential for the progression of the neurodegeneration associated with Alzheimer’s disease.74 Consequently, several studies have highlighted the potential therapeutic use of non-steroidal COX-2 inhibitors to delay the advancement of Alzheimer’s disease.75 Therefore, for such purpose and as another step forward to in vitro test EPSF6 anti-AChE activity.