TNF and depressive disorder: While the direct impact of SARS-CoV-2 on the brain and resulting neurological and psychiatric symptoms remains uncertain, the virus-induced cytokine storm, characterized by increased levels of serum C-reactive protein, interleukins (IL-1, IL-6, IL-10), and tumor necrosis factor (TNF-alpha), is associated with psychiatric symptoms, including depression, anxiety, stress, and suicidality [4].