Also, when CA 19-9 alone did not succeed in cancer diagnosis, a 13.2% sensitivity spike in pancreatic cancer detection could be achieved when markers like LRG1 and TIMP1 were used together with CA 19-9 [23]. The patients diagnosed with PDAC demonstrated atypical processing of apolipoprotein (APO), producing various isomers. This evidence concerns the gene AOPEP and familial pancreatic carcinoma.