Seven (9%) had a documented T1DM diagnosis prior to ICI treatment, ten (13%) developed non-insulin dependent T2DM during treatment, seven (9%) had worsening of T2DM during ICI treatment leading to a nonpermanent insulin requirement, and two patients (3%) did not have sufficient data to confirm a T1DM diagnosis outside of their listed diagnosis. This evidence concerns the gene INS and type 1 diabetes mellitus.