METTL3 and inflammatory response: In addition, elevated METTL3 and m6A modifications were found in bone samples from patients with periprosthetic joint infection (64); KEGG analysis demonstrated that differentially methylated genes are mainly enriched in Th17 cell differentiation and the IL-17 signaling pathway, indicating that Th17 cells and METTL3 may contribute to the pathogenesis of periprosthetic joint inflammation (64).