We comprehensively summarize METTL3 expression changes and related pathogenesis in inflammatory diseases, including atherosclerosis, myocardial infarction (MI), non-alcoholic liver disease, hyperuricemia (HUA), diabetes nephropathy, osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis, psoriasis, inflammatory bowel disease (IBD), sepsis, pneumonia, and tumor. Here, METTL3 is linked to intervertebral disk degenerative disorder.