METTL3 and inflammatory bowel disease: Subsequently, METTL3 was found to be elevated in ulcerative colitis tissue from patients with IBD, a dextran sulfate sodium-induced IBD mouse model, and LPS-treated MODE-K cells, while in vivo and in vitro knockdown of METTL3 reduced levels of proinflammatory cytokines and inflammatory enzymes and inhibited p65 phosphorylation (91).