found that METTL3 levels were increased in NPCs from patients with IDD (87), while METTL3 depletion resulted in the reduction of siah E3 ubiquitin protein ligase 1 (SIAH1) mRNA stability, which induced apoptosis, inflammation, and senescence, as well as decreasing ECM synthesis in NPCs (87). Here, METTL3 is linked to intervertebral disk degenerative disorder.