The lung injury was examined in experimental mice at 24 h after infection; we found that myeloid TPST2 knockout could attenuate the inflammation response of acute lung injury in mice infected by different types of S. aureus and that the pathogenicity of △HlgACB S. aureus infection was significantly lowered in experimental mice compared with that of control and complemented pHlgACB S. aureus (Figures 3A, B). This evidence concerns the gene TPST2 and infection.