The loss of proinflammatory cells, enrichment of inhibitory cell types and the low expression of immune checkpoint proteins may lead to an immune silence environment for EGFR-mutated LUAD, i.e., EGFR-mutated tumor cells secrete cytokines to recruit various immunosuppressive cells, while activated immune cells (CXCL9+TAM and CD8+TRM) were seriously insufficient. Here, EGFR is linked to neoplasm.