APOE and neoplasm: (33) conducted scRNA-seq to analyze the TME of 18 LUAD patients, and identified the characteristic genes of tumor infiltrating macrophages, such as TREM2, CD81, MARCO, APOE, etc. In addition, analysis with scRNA-seq found that vascular endothelial cells from NSCLC patients reduced their antigen presentation and the homing activity of immune cells through remodeling, thereby promoting tumor immune tolerance (34, 66).