(33) conducted scRNA-seq to analyze the TME of 18 LUAD patients, and identified the characteristic genes of tumor infiltrating macrophages, such as TREM2, CD81, MARCO, APOE, etc. In addition, analysis with scRNA-seq found that vascular endothelial cells from NSCLC patients reduced their antigen presentation and the homing activity of immune cells through remodeling, thereby promoting tumor immune tolerance (34, 66). The gene discussed is TREM2; the disease is neoplasm.