To select the most discriminating genes dysregulated in sepsis development, we used LASSO analysis to obtain nine key genes (CHPT1, CPEB4, DNAJC3, MAFG, NARF, SNX3, S100A9, S100A12, METTL9) from the U42 cluster (Figure 5C). The gene discussed is MAFG; the disease is Sepsis.