The signature enriched in GTF2I mutant tumors were COSMIC 1: spontaneous deamination of 5-methylcytosine and COSMIC 5: unknown etiology, whereas in TP53 mutant tumors, COSMIC 1: spontaneous deamination of 5-methylcytosine and COSMIC 6: defective mismatch repair (even if the thymic carcinoma with microsatellite instability was removed from the analysis; Supplementary Figures S3 and S4). The gene discussed is TP53; the disease is thymic carcinoma.