The major findings in this group include the detection of ASXL1 p.Gly646TrpfsTer12 (variant described in MF and connected with AML progression), RUNX1 p.Leu56Ser and ZRSR2 p.Arg169Ter (variants described in MPN and MDS and connected with fibrotic progression) and U2AF1 p.Gln157Pro (described in MDS, MPN/MDS, MF and secondary AML). The gene discussed is RUNX1; the disease is myeloproliferative neoplasm.