TARDBP and amyotrophic lateral sclerosis: Genetic alteration of the expression levels of TDP-43 in ALS mouse models is associated with both increased and decreased dendritic branching and synapse number, suggesting a role in regulating the structural plasticity of synapses (Majumder et al., 2012; Fogarty et al., 2016; Ling, 2018; Jiang et al., 2019).