IRS2 and Insulin resistance: Notably, new-onset hyperglycemia has been associated with SARS-CoV-2 because non-diabetic COVID-19 patients were found to have increased risk of insulin resistance (Chen et al., 2021; Wihandani et al., 2023), which may be associated with Mpro cleavage of IRS2 (Pablos et al., 2021).