Multiple bioinformatics analyses were used to extract and analyse datasets from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and the Gene Expression Omnibus (GEO) database to investigate the potential oncogenic mechanisms, including correlations between PIK3R4 and the prognosis, immunity and immune checkpoints, of PIK3R4 in DLBCL. The gene discussed is PIK3R4; the disease is diffuse large B-cell lymphoma.