In addition, although this paper revealed the relationship between SIK1 and the TGF-β signaling pathway in CRC and found its relationship with EMT and OXA drug resistance, the study of whether there is an interaction between EMT and OXA drug resistance has not been in depth, although there is literature supporting the potential correlation between EMT and OXA. The gene discussed is TGFB1; the disease is colorectal carcinoma.