For example, the HOXB gene is a prognostic factor in breast cancer 14, HOXA13 expression impaired the chemotherapy in gastric cancer cells 15, HOXB5 promotes metastasis in hepatocellular carcinoma 16 and HOXA13, HOXD13, and HOXC6 were promoted colorectal cancer 17-19. This evidence concerns the gene HOXA13 and colorectal cancer.