The results indicated that CCNF played a significant role in the prognosis of several cancers, such as breast invasive carcinoma (BRCA), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), sarcoma (SARC), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), mesothelioma (MESO), brain lower grade glioma (LGG), skin cutaneous melanoma (SKCM), and adrenocortical carcinoma (ACC), acting as a high-risk factor. The gene discussed is CCNF; the disease is cutaneous melanoma.