Activation of PPARδ in the nucleus can form a stable complex with TC45, which can prolong the time that TC45 stays in the nucleus, thereby reducing IL-6-induced insulin resistance, promoting the inactivation of STAT3-suppressor Of cytokine signaling 3(SOCS3) signaling, and alleviating inflammatory response (Mattila et al., 2010). This evidence concerns the gene SOCS3 and Insulin resistance.