IL-6, IL-1β, and TNF-α are common inflammatory factors, and significantly higher IL-6 and TNF-α levels are reported in patients with insomnia than in healthy individuals, whereas decreasing their levels had a calming effect (Burgos et al., 2006; Motivala, 2011; Xia et al., 2013). The gene discussed is IL1B; the disease is insomnia measurement.