The PI3K/Akt signaling pathway regulates the normal activity of neuronal cells, and elevated levels of phosphatidylinositol 3-kinase (PI3K) and protein kinase B (Akt) modulate the activity of genes involved in the transduction of inflammatory cytokines driving insomnia pathogenesis (Meng et al., 2013). This evidence concerns the gene AKT1 and insomnia.