A study demonstrated that using the C1C2 structural domain of cadherin to present tumor-associated antigens such as carcinoembryonic antigen (CEA) and human epidermal growth factor receptor 2 (HER2) on the surface of exosomes derived from antigen-presenting cells enhanced T and B cell responses, thereby promoting antitumor immune responses (Hartman et al., 2011). Here, ERBB2 is linked to neoplasm.