ICAM1 and neoplasm: Zhang et al. showed that ICAM-1 on the surface of tumor exosomes mediates the adhesion between tumor exosomes and CD8+ T cells, and this adhesion is a prerequisite for the immunosuppressive effect mediated by tumor exosomes PD-L1, suggesting that tumor exosomes, as a complete functional unit, have a synergistic effect on their surface molecules (Zhang et al., 2022).