CaM then binds to CaN to form an active phosphatase that catalyzes subunit A (CnA) and phosphorylates- extracellular signal-regulated kinase (p-ERK1/2) as targets to suppress Drp1 phosphorylation at S637 and induce Drp1 phosphorylation at S616, respectively, facilitating mitochondrial fission and speeding up cardiac hypertrophy induced by high glucose (113, 122). This evidence concerns the gene DNM1L and cardiac hypertrophy.