CaM then binds to CaN to form an active phosphatase that catalyzes subunit A (CnA) and phosphorylates- extracellular signal-regulated kinase (p-ERK1/2) as targets to suppress Drp1 phosphorylation at S637 and induce Drp1 phosphorylation at S616, respectively, facilitating mitochondrial fission and speeding up cardiac hypertrophy induced by high glucose (113, 122). Here, NUP214 is linked to cardiac hypertrophy.