Androgen-sensitive PCa (LNCaP, with lowest PIK3CD-S/PIK3CD-L ratio), androgen-independent PCa (22Rv1 and MDA PCa 2b, with high PIK3CD-S/PIK3CD-L ratios), colon, lung and breast cancer cell lines (HT-29, A549 and MCF-7, with higher PIK3CD-S/PIK3CD-L ratios among each cancer types) were selected as in-vitro endocrine/solid tumor cell models for this experiment. Here, PIK3CD is linked to breast carcinoma.