The RT-PCR results have revealed that the androgen-independent PCa cell lines MDA PCa 2b, PC-3, 22Rv1 and DU-145 have higher PIK3CD-S/PIK3CD-L (S/L) ratios, 2.24, 1.58, 1.45, and 0.67. Here, PIK3CD is linked to posterior cortical atrophy.