Although FCGR2A has rarely been reported in HNSCC, our study showed that immune cells, such as memory B, plasma, resting memory CD4+ T, activated memory CD4+ T, follicular helper T, resting and activated dendritic, activated mast, resting and activated NK cells, M0, M1, and M2 macrophages, and neutrophils, were closely associated with FCGR2A expression in HNSCC. The gene discussed is CD4; the disease is head and neck squamous cell carcinoma.