TRDD3 and acute lymphoblastic leukemia: As expected, most of these AB TRD clones were incomplete TRDD2-TRDJ, TRDV-TRDD3, TRDD2-TRDD3 rearrangements or combined TRD-TRAJ29 junctions (Figure 1B; 75.6%, 1132/1497), in line with previous results of TRD rearrangement profiles of BCP-ALL.5,11 However, in 190 of 839 (22.6%) patients, we identified 365 complete TRDV-TRDJ rearrangements (at the median of 2, ranging from 1 to 7 rearrangements/patient), which are generally assumed not to represent BCP-ALL (Figure 1B, C; Suppl.