HUWE1 and neoplasm: p14arf can trigger apoptosis by binding and sequestering the ubiquitin ligases Mdm2 and ARF-BP1 in the nucleolus, thus stabilizing P53 in the nucleoplasm (Ozenne et al., 2010; Veneziano et al., 2016; Cilluffo et al., 2020), but also shows tumour-suppressive activities that are independent of p53 through interactions with TIP60, TOPO I and C1QBP (Karayan et al., 2001; Eymin et al., 2006; Itahana and Zhang, 2008).