Importantly from a clinical perspective, we found FH expression to be suppressed in whole blood samples of systemic lupus erythematosus (SLE) patients,5 where autoantibodies to dsRNA have previously been detected, indicating that FH suppression and associated impairment in mitochondrial bioenergetics may be drivers of disease pathogenesis in SLE. The gene discussed is FH; the disease is systemic lupus erythematosus.