Using microarray and mass spectrometry data from liver samples of patients with acute-on-chronic liver failure (ACLF), one recent study has identified that the exosomal miR-20a-5p/intrahepatocyte CXCL8 axis potentially contributes to the reduction of liver inflammation in ACLF in the context of MSCs-based therapies, highlighting that CXCL8 acts as a promising target for alleviating liver injury [98]. The gene discussed is CXCL8; the disease is acute-on-chronic liver failure.