RUNX1 and Duchenne muscular dystrophy: Hence, similarly to what is observed in the heart (see previous section), RUNX1 expression is significantly increased in samples of muscle dystrophies, including mouse models of Duchenne muscular dystrophy (DMD) [121] and amyotrophic lateral sclerosis [122], myopathy patients—including DMD, Emery-Dreifuss Muscular Dystrophy and Acute Quadriplegic Myopathy—[123], as well as in cardiotoxin-treated muscles [124] and during ischemia reperfusion-induced muscle injury [125].