CD4 and neoplasm: For example, in an HNSCC mouse model with overexpressed LAG-3 on CD4+ and CD8+ T cells and Tregs, administration of LAG-3-Ig retarded tumor growth in a manner associated with an enhanced systemic antitumor response; specifically, LAG-3-Ig potentiated the cytotoxicity of CD8+ T cells and reduced the population of immunosuppressive cells [73].