Moreover, TIM-3 is also expressed on certain malignant cells, such as melanoma [39, 40], myeloid leukemia [41], non-small cell lung cancer (NSCLC) [42], prostate cancer [43], osteosarcoma [44], colon carcinoma [45], and hepatocellular carcinoma (HCC) cells [46]. Here, HAVCR2 is linked to Familial prostate cancer.