ZGGS15 is a humanized anti-LAG-3 and anti-TIGIT BsAb that not only blocks the signaling pathways activated by LAG-3 and its ligand MHC-II but also activates the TCR signaling pathway, thereby promoting the activation and proliferation of T and NK cells and cytokine production, synergistically enhancing the ability of the immune system to kill tumor cells. This evidence concerns the gene TIGIT and neoplasm.