Additionally, TIM-3 was used to develop a second-generation 41BB-CD19-CAR linked with a switch receptor T3/28 chimera, known as T3/28 CAR-T cells, which significantly prolonged the persistence of CAR-T cells and showed potent antitumor activity both in vitro and in MM model mice [217]. Here, HAVCR2 is linked to Miyoshi myopathy.