SREBF2 and Duchenne muscular dystrophy: One previous study showed that lipid metabolism might be a critical metabolic disturbance in DMD, and studies regarding the skeletal muscle of mdx mice (a genetic model of DMD) uncovered dysregulation of cholesterol and fatty acid metabolism transcription factors (SREBP-1 and SREBP-2), disruption of the mevalonate pathway, and accumulation of cholesterol in dystrophic muscles [10].