MDM2 and precursor B-cell acute lymphoblastic leukemia: There was a significant positive, linear correlation between IGF2BP1 expression with some of its putative targets (CDK6, MDM2, PRKCB, RAG1) (Supplementary Figure S6). BCL2 is one of the major genes which drives glucocorticoid resistance in B-ALL by modulating the glucocorticoid receptor (GR: NR3C1) activity.