IGF2BP1 and cancer: IGF2BP1 overexpression has been reported in various human cancers, including hepatocellular carcinomas, melanomas [18], neuroblastomas [19], breast cancer (overexpressed in ~58.5% of cases) [20], colorectal cancer (stage III/IV: 61.3% and stage I/II: 40%) [21], and ovarian cancer (69%) [22], and is also associated with poor prognosis and aggressive tumor behavior.