As the typical pattern like in Alzheimer’s disease (i.e., increased tau protein, decreased amyloid-ß, increased p-tau, and decreased amyloid-ß 42/40 ratio) [15] could, thus, not be detected, a typical AD-like neurodegeneration process is apparently not existent in our PMS cohort. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.