In HepG2-derived xenograft model and a PDX model of HCC, CDK9 inhibitor, PHA767491 and oroxylin A (OA) from Scutellaria baicalensis significantly decreased the protein expression of CDK9, PINK1, PRKN, p-SIRT1, FOXO3 and BNIP3 in tumor tissues. This evidence concerns the gene PRKN and neoplasm.