In a study investigating the role of MYC and E2F1 genes in the development of liver cancer, 22% of 6-month-old and 100% of 12-month-old c-Myc/E2F1 double transgenic mice were induced to develop liver tumors, while only 23% of Alb/c-Myc and 60% of Alb/E2F1 mice were induced to tumors, and no tumors were induced in c-Myc or E2F1 deletion alone mice [48]. Here, E2F1 is linked to liver cancer.