Heterogeneity score for somatic mutations in APC, TP53, and other genes did not show any correlation between primary and metastatic tumours (APC: r = 0.0122, r2 = 0.0001, P = 0.961; TP53: r = 0.256, r2 = 0.065, P = 0.264; other mutations: r = 0.383, r2 = 0.147, P = 0.395). This evidence concerns the gene APC and neoplasm.