Indeed, not only were different lysosomal enzymes, including Gba, Neu1, and Aga, underrepresented in MU ZF, but lysosomal membrane proteins Lamp and Limp/Cd63 and transport proteins Ap-1 and Ap-3 were also underrepresented, consistent with disrupted autophagy in this FD model. This evidence concerns the gene CD63 and Fabry disease.