Referring to mining of the GEO database, the GSE26309 dataset was divided into AGS gastric cancer cells Control group, RhoA activator group (LPA), RhoA GEF exchange factor (NET1) knockdown group (shNET1), NET1 knockdown and RhoA activator group (shNET1-LPA) (Fig. 3A). The gene discussed is RHOA; the disease is gastric cancer.