SENP1 and pulmonary fibrosis: Overexpression of SENP1 in LR-MSCs can stimulate the Wingless/Integrated (WNT)/β-catenin and Hedgehog/Glioma-associated oncogene homolog (GLI) signaling pathways by deSUMOylation of critical proteins, and encourage the transformation of LR-MSCs into myofibroblasts, exacerbating the development of pulmonary fibrosis(Sun et al. 2022).