While amyloid deposit is widely considered as the initial cause of Alzheimer’s disease [49], timing of CSF A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β42 was unclear as moderate severity was reached later than for CSF p-tau, a consistent result with previous disease progression model [50]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.