CRISPR/dCas13b-ALKBH5 could downregulate m<sup>6</sup>A methylation level of PLOD2, which plays an important role in PLOD2-mediated cell proliferation and apoptosis in GC-2 cells.<h4>Results</h4>PLOD2 was frequently exhibited with high m<sup>6</sup>A methylation and expression level in the testes of varicocele rats compared with control. Here, PLOD2 is linked to varicocele.