Tumour hypoxia leads to the production and activation of hypoxia-inducible factor (HIF) family members, including HIF-1 and HIF-2; these HIFs’ proteins later activate more genes that promote hypoxia such as the GLUT-1 and carbonic anhydrase-9 (CAIX) [7] which are both well-known membrane-bound biomarkers that induce and increase the hypoxic condition in solid [8]. Here, CA9 is linked to neoplasm.