ROSI also reduced the high reaction of lipid peroxidation induced in renal fibrosis (fluorescence was shifted from red to green to represent reactive oxygen species) and decreased the expression of 4-HNE in TGF-β-treated cells (Fig. 3a), suggesting that ROSI inhibits lipid peroxidation under kidney fibrosis. Here, TGFB1 is linked to renal fibrosis.