Wang et al.45 demonstrated that ACSL4 plays a protector in the ferroptosis of AKI by knocking out ACSL4 in TECs of mice In human acute tubular injury, the expression of ACSL4 in TECs is upregulated, accomplished with the elevation of serum creatinine and blood urea nitrogen and the declined level of eGFR46. The gene discussed is ACSL4; the disease is acute kidney injury.