Furthermore, we constructed human and murine CUL4B (SYBC1)/Cul4b (MB49)-KO cell lines and found that tumor cells lacking CUL4B showed enhanced STING stability and IFN-β production under treatment of cisplatin, RT, or cGAMP (Fig. 6H and Supplementary Fig. 6A, B). Here, IFNB1 is linked to neoplasm.