RN7SL1 is normally shielded by the RBP SRP9/14, however when unshielded, it is transferred to immune cells, generating an inflammatory response, acting as a damage-associated molecular pattern (DAMP), activating retinoic acid-inducible gene I (RIG-I), increasing proliferation, metastasis and therapy resistance in BC [103]. The gene discussed is RIGI; the disease is breast cancer.