In this study, strong upregulation of 5 lncRNAs (HISLA, LINC01234, LINC02432, LINC01678 and LINC01493) in an EV-secretion-dependent manner was validated by qRT-PCR and suppression of HISLA in TAMs abrogated the co-culture driven induction of aerobic glycolysis in BC cells. The gene discussed is HISLA; the disease is breast cancer.