GRN and breast cancer: miR-5100 was upregulated in Progranulin knockout TAMs and the group suggested that, through miR-5100-mediated inhibition of the CXCL12/CXCR4 axis, this reduced the invasiveness and metastatic potential of BC cells due to the pivotal role of CXCL12/CXCR4 axis in cancer cell migration, proliferation and gene regulation.