Regarding IL-6, 72 vitreal proteins were shown to be altered in mice treated with STZ as compared with controls; however, in 52 of the 72 proteins, these effects were mitigated in mice treated with an IL-6 inhibitor 10 weeks after STZ treatment, indicating the importance of IL-6 at the 10-week timepoint following diabetes induction [40]. This evidence concerns the gene IL6 and diabetes mellitus.