Vinores’ group investigated streptozotocin (STZ)-treated mice and Ins2Akita/+ mice with a TNF-α knockout, showing that there was a reduction in leucostasis by 1–2 weeks of diabetes, but TNF-α does not affect blood–retina barrier breakdown or CC3 levels until 3 months of development [39]. The gene discussed is TNF; the disease is diabetes mellitus.