PGF and acute myocardial infarction: Previous studies have shown that the PLGF-FLT1 axis functioned endothelial cell growth and angio-/vasculogenesis37,38, and that exogenous administration of recombinant human PLGF protein could reduce infarct size and improve cardiac function by enhancing angiogenesis and arteriogenesis after acute myocardial infarction in mice39 as well as in chronic myocardial ischemia in pigs11.